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1.
Ann R Coll Surg Engl ; 103(7): 496-498, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-34192485

RESUMEN

As the COVID-19 pandemic progressed across the UK and Northern Ireland in March 2020, our otolaryngology department began to make preparations and changes in practice to accommodate for potentially large numbers of patients with COVID-19 related respiratory illness in the hospital. We retrospectively reviewed the number of non-elective admissions to our department between the months of January and May in 2019 and 2020. A significant reduction in admissions of up to 94% during the months of the pandemic was observed. Our practice shifted to manage patients with epistaxis and peritonsillar abscess on an outpatient basis, and while prospectively collecting data on this, we did not observe any significant adverse events. We view this as a positive learning point and change in our practice as a result of the COVID-19 pandemic.


Asunto(s)
Procedimientos Quirúrgicos Ambulatorios/tendencias , COVID-19/prevención & control , Procedimientos Quirúrgicos Otorrinolaringológicos/tendencias , Admisión del Paciente/tendencias , Servicio de Cirugía en Hospital/tendencias , Procedimientos Quirúrgicos Ambulatorios/normas , Procedimientos Quirúrgicos Ambulatorios/estadística & datos numéricos , COVID-19/epidemiología , COVID-19/transmisión , Epistaxis/cirugía , Humanos , Control de Infecciones/normas , Irlanda del Norte/epidemiología , Procedimientos Quirúrgicos Otorrinolaringológicos/normas , Procedimientos Quirúrgicos Otorrinolaringológicos/estadística & datos numéricos , Pandemias/prevención & control , Admisión del Paciente/normas , Admisión del Paciente/estadística & datos numéricos , Absceso Peritonsilar/cirugía , Estudios Retrospectivos , Servicio de Cirugía en Hospital/normas , Servicio de Cirugía en Hospital/estadística & datos numéricos
2.
Plast Reconstr Surg ; 148(1): 168e-169e, 2021 07 01.
Artículo en Inglés | MEDLINE | ID: mdl-34110314

Asunto(s)
COVID-19/prevención & control , Control de Infecciones/organización & administración , Pandemias/prevención & control , Servicio de Cirugía en Hospital/organización & administración , Cirugía Plástica/organización & administración , COVID-19/diagnóstico , COVID-19/epidemiología , COVID-19/transmisión , Prueba de COVID-19/normas , Prueba de COVID-19/estadística & datos numéricos , Prueba de COVID-19/tendencias , Egipto/epidemiología , Procedimientos Quirúrgicos Electivos/normas , Procedimientos Quirúrgicos Electivos/estadística & datos numéricos , Procedimientos Quirúrgicos Electivos/tendencias , Política de Salud , Humanos , Control de Infecciones/normas , Control de Infecciones/estadística & datos numéricos , Control de Infecciones/tendencias , Procedimientos de Cirugía Plástica/normas , Procedimientos de Cirugía Plástica/estadística & datos numéricos , Procedimientos de Cirugía Plástica/tendencias , SARS-CoV-2/aislamiento & purificación , Servicio de Cirugía en Hospital/normas , Servicio de Cirugía en Hospital/estadística & datos numéricos , Servicio de Cirugía en Hospital/tendencias , Cirugía Plástica/normas , Cirugía Plástica/estadística & datos numéricos , Cirugía Plástica/tendencias , Telemedicina/organización & administración , Telemedicina/normas , Telemedicina/estadística & datos numéricos , Centros de Atención Terciaria/organización & administración , Centros de Atención Terciaria/normas , Centros de Atención Terciaria/estadística & datos numéricos , Centros de Atención Terciaria/tendencias , Triaje/organización & administración , Triaje/normas , Triaje/estadística & datos numéricos , Triaje/tendencias
4.
Rev. medica electron ; 43(2): 3061-3073, mar.-abr. 2021. tab
Artículo en Español | LILACS, CUMED | ID: biblio-1251926

RESUMEN

RESUMEN Introducción: la propia asistencia médica provoca, en determinadas situaciones, problemas de salud que pueden llegar a ser importantes para el enfermo. El análisis de la mortalidad es uno de los parámetros utilizados para investigar la seguridad en la realización de procederes de cirugía mayor. Objetivo: determinar los factores asociados a la mortalidad operatoria en cirugías mayores. Materiales y métodos: se realizó un estudio observacional, descriptivo y retrospectivo, de los pacientes que fallecieron tras la realización de una cirugía mayor, en el Hospital Militar Docente Dr. Mario Muñoz Monroy, de Matanzas, en el período comprendido de enero de 2011 a diciembre de 2019. Resultados: la tercera edad aportó 77,3 % de los fallecidos. La hipertensión arterial, diabetes mellitus y cardiopatía isquémica fueron las principales comorbilidades. El abdomen agudo fue el diagnóstico operatorio más frecuente con 98 (58,3 %). Las complicaciones aportaron el 11,9 % de los fallecidos; los eventos adversos, 29,7 %, y por el curso natural de la enfermedad, murió un 58,3 %. El síndrome de disfunción múltiple de órganos y el shock séptico resultaron las principales causas de muerte (62 %). Conclusiones: la mortalidad operatoria estuvo asociada a factores de riesgo como edad avanzada, enfermedades crónicas y cirugía de urgencia. Los eventos adversos elevan la incidencia de mortalidad en cirugía mayor. Las infecciones son la principal causa de mortalidad operatoria (AU).


ABSTRACT Introduction: medical care itself causes, in certain situations, health problems that could be very important for the patient. The mortality analysis is one of the parameters used to study safety performing procedures of major surgery. Objective: to determine the factors associated to operatory mortality in major surgeries. Materials and methods: a retrospective, descriptive and observational study was carried out of the patients who passed away after undergoing a major surgery in the Military Hospital Dr. Mario Munoz Monroy in the period between January 2011 and December 2019. Results: 77.3 % of the deceased were elder people. The main co-morbidities were arterial hypertension, diabetes mellitus and ischemic heart disease. The most frequent surgery diagnosis was acute abdomen with 98 patients (58.3 %). Complications yielded 11.9 % of the deceases, adverse events 29.7 % and 58.3 % died due to the natural course of the disease. The organs multiple dysfunction syndrome and septic shock were the main causes of dead (62 %). Conclusions: operatory mortality was associated to risk factors like advanced age, chronic diseases and emergency surgery. The adverse events increase mortality incidence in major surgery. Infections are the main causes of operatory mortality (AU).


Asunto(s)
Humanos , Masculino , Femenino , Procedimientos Quirúrgicos Operativos/mortalidad , Mortalidad Hospitalaria/tendencias , Quirófanos/métodos , Cirugía General/métodos , Servicio de Cirugía en Hospital/normas , Servicio de Cirugía en Hospital/tendencias , Pacientes Internos , Complicaciones Intraoperatorias/cirugía
5.
J Plast Reconstr Aesthet Surg ; 74(1): 199-202, 2021 01.
Artículo en Inglés | MEDLINE | ID: mdl-33645504

RESUMEN

Coronavirus disease-2019 (COVID-19) is the infectious disease caused by the recently discovered coronavirus, SARS-CoV2. This new virus and disease were unknown before the outbreak began in Wuhan, China, in December 2019. The number of publications with regard to COVID-19-related information is exponentially increasing, but there are also some retracted papers appearing on PubMed, including those retracted from The Lancet Global Health and the New England Journal of Medicine. In a PubMed search for "COVID," there were 1595 articles by April 1, 2020. As of June 30, the number of articles has now reached 25,913. In this editorial, 4 specific areas of information are looked at but the principles apply to many other areas of medicine. The specifics looked at are PPE for tracheostomy, testing for COVID-19, pregnancy and COVID-19, and surgical expectations during redeployment. We must make no mistake that we are seeing a disease that modern medicine has never encountered before. This article is not aimed at belittling or dismissing any of the advice of the Royal Colleges' or PHE advice, but it demonstrates the tsunami of information and the ambiguity that surgeons are experiencing throughout the UK right now. This is unlikely to be the end of progression regarding healthcare planning and development for unencountered viruses9. In the next few months and beyond, there are likely to be adaptions and revisions of more documents advising on various aspects of healthcare with regard to COVID-19 management and for possible future viruses not yet seen by the modern world before.


Asunto(s)
COVID-19 , Control de Infecciones , Procedimientos de Cirugía Plástica , Servicio de Cirugía en Hospital , COVID-19/epidemiología , COVID-19/prevención & control , Humanos , Control de Infecciones/instrumentación , Control de Infecciones/métodos , Control de Infecciones/organización & administración , Difusión de la Información , Innovación Organizacional , Procedimientos de Cirugía Plástica/métodos , Procedimientos de Cirugía Plástica/tendencias , SARS-CoV-2 , Servicio de Cirugía en Hospital/organización & administración , Servicio de Cirugía en Hospital/tendencias
6.
Surg Today ; 51(6): 1001-1009, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-33392752

RESUMEN

PURPOSES: Balancing scheduled surgery and trauma surgery is difficult with a limited number of surgeons. To address the issues and systematize education, we analyzed the current situation and the effectiveness of having a trauma team in the ER of a regional hospital. METHODS: This retrospective study analyzed the demographics, traumatic variables, procedures, postoperative morbidities, and outcomes of 110 patients who underwent trauma surgery between 2012 and 2019. The trauma team was established in 2016 and our university hospital Emergency Room (ER) opened in 2012. RESULTS: Blunt trauma accounted for 82% of the trauma injuries and 39% of trauma victims were transported from local centers to our institute. The most frequently injured organs were in the digestive tract and about half of the interventions were for hemostatic surgery alone. Concomitant treatments for multiple organ injuries were performed in 31% of the patients. The rates of postoperative severe complications (over Clavien-Dindo IIIb) and mortality were 10% and 13%, respectively. Fourteen (12.7%) of 24 patients who underwent damage-control surgery died, with multiple organ injury being the predominant cause of death. CONCLUSION: Systematic education or training of medical students and general surgeons, as well as the co-operation of the team at the regional academic institute, are necessary to overcome the limited human resources and save trauma patients.


Asunto(s)
Servicio de Urgencia en Hospital/estadística & datos numéricos , Servicio de Urgencia en Hospital/tendencias , Planificación Hospitalaria/organización & administración , Planificación Hospitalaria/estadística & datos numéricos , Planificación Hospitalaria/tendencias , Grupo de Atención al Paciente , Servicio de Cirugía en Hospital/estadística & datos numéricos , Servicio de Cirugía en Hospital/tendencias , Heridas y Lesiones/epidemiología , Heridas y Lesiones/cirugía , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Causas de Muerte , Niño , Femenino , Humanos , Japón/epidemiología , Masculino , Persona de Mediana Edad , Traumatismo Múltiple/mortalidad , Complicaciones Posoperatorias/epidemiología , Estudios Retrospectivos , Cirujanos/educación , Cirujanos/provisión & distribución , Heridas y Lesiones/mortalidad , Adulto Joven
7.
J Surg Res ; 260: 300-306, 2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33360755

RESUMEN

BACKGROUND: COVID-19 has mandated rapid adoption of telehealth for surgical care. However, many surgical providers may be unfamiliar with telehealth. This study evaluates the perspectives of surgical providers practicing telehealth care during COVID-19 to help identify targets for surgical telehealth optimization. MATERIALS AND METHODS: At a single tertiary care center with telehealth capabilities, all department of surgery providers (attending surgeons, residents, fellows, and advanced practice providers) were emailed a voluntary survey focused on telehealth during the pandemic. Descriptive statistics and Mann-Whitney U analyses were performed as appropriate on responses. Text responses were thematically coded to identify key concepts. RESULTS: The completion rate was 41.3% (145/351). Providers reported increased telehealth usage relative to the pandemic (P < 0.001). Of respondents, 80% (116/145) had no formal telehealth training. Providers estimated that new patient video visits required less time than traditional visits (P = 0.001). Satisfaction was high for several aspects of video visits. Comparatively lower satisfaction scores were reported for the ability to perform physical exams (sensitive and nonsensitive) and to break bad news. The largest barriers to effective video visits were limited physical exams (55.6%; 45/81) and lack of provider or patient internet access/equipment/connection (34.6%; 28/81). Other barriers included ineffective communication and difficulty with fostering rapport. Concerns regarding video-to-telephone visit conversion were loss of physical exam/visual cues (34.3%; 24/70), less personal interactions (18.6%; 13/70), and reduced efficiency (18.6%; 13/70). CONCLUSIONS: Telehealth remains a new experience for surgical providers despite its expansion. Optimization strategies should target technology barriers and include specialized virtual exam and communication training.


Asunto(s)
COVID-19/prevención & control , Cirujanos/estadística & datos numéricos , Servicio de Cirugía en Hospital/organización & administración , Telemedicina/organización & administración , Comunicación por Videoconferencia/organización & administración , COVID-19/epidemiología , COVID-19/transmisión , Comunicación , Humanos , Pandemias/prevención & control , Satisfacción Personal , Distanciamiento Físico , Relaciones Médico-Paciente , Mejoramiento de la Calidad , Cirujanos/psicología , Servicio de Cirugía en Hospital/estadística & datos numéricos , Servicio de Cirugía en Hospital/tendencias , Encuestas y Cuestionarios/estadística & datos numéricos , Telemedicina/estadística & datos numéricos , Telemedicina/tendencias , Centros de Atención Terciaria/organización & administración , Centros de Atención Terciaria/estadística & datos numéricos , Centros de Atención Terciaria/tendencias , Comunicación por Videoconferencia/estadística & datos numéricos , Comunicación por Videoconferencia/tendencias
10.
Med Glas (Zenica) ; 18(1): 133-137, 2021 02 01.
Artículo en Inglés | MEDLINE | ID: mdl-33345530

RESUMEN

Aim A SARS Coronavirus 2 (COVID-19) pandemic drastically changed the way the health system works. In Croatia, lockdown measures to curb virus spread lasted from March to May 2020, and all non-essential medical procedures and patients' visits have been cancelled. The study aimed to compare patients' flow and interventions in the surgical department before, during and after the lockdown period. Methods This cross-sectional study analysed the workload at the Maxillofacial and Oral Surgery Department (Department), Osijek University Hospital, during the COVID-19 pandemic (March-May 2020) and four subsequent months. The same period of 2019 was compared as a control. The data were subtracted from hospitals' electronic database. Results During COVID-19 lockdown from March to May 2020 the number of hospitalizations (306 vs. 138), surgical procedures (306 vs. 157), and scheduled outpatient visits (2009 vs. 804), dropped significantly as compared to 2019. The number of skin tumour removals was halved (from 155 in 2019 to 58 in 2019) (p<0.001), and the number of emergency patients was unchanged in the 3-month period. A significant decrease in outpatient visits and hospital admissions continued after the lockdown (p<0.001). Conclusion A decrease in the number of outpatient visits, hospitalizations, and tumour removals may result in larger proportions of patients with advanced cancers in the future. The second wave of COVID-19 pandemic is ongoing, and special effort must be paid to reduce the number of cancer patients receiving suboptimal treatment.


Asunto(s)
COVID-19 , Neoplasias , Servicio de Cirugía en Hospital/tendencias , Cirugía Bucal/tendencias , Carga de Trabajo , Control de Enfermedades Transmisibles , Croacia , Estudios Transversales , Humanos , Neoplasias/epidemiología , Pandemias
14.
J Surg Res ; 256: 76-82, 2020 12.
Artículo en Inglés | MEDLINE | ID: mdl-32683060

RESUMEN

The coronavirus disease 2019 (COVID-19) pandemic has brought most ongoing clinical trials to a standstill, while at the same time emphasizing the need for new therapeutic treatments and strategies to mitigate the morbidity and mortality related to COVID-19. Recent publication of several observational studies has generated much discussion surrounding efficacy of drugs including hydroxychloroquine, azithromycin, and remdesivir, stressing the need for high-quality prospective, randomized control trials in patients with COVID-19. Ongoing "stay at home" orders and institutional policies mandating "work from home" for nonessential employees, which includes most research personnel, have impacted the ability to implement and conduct clinical studies. This article discusses the approach of an experienced clinical trials unit to make adjustments for ongoing studies and ensure the safety of study participants. At the same time, plans were implemented to continue collection of data to achieve endpoints, safely enroll and follow participants in studies offering potential benefit, and quickly implement new COVID-19 clinical trials. The existence of a Division of Clinical Research with regulatory, budgeting, contracting, and coordinating expertise within a department of surgery can successfully accommodate a crisis situation and rapidly adapt to new requirements for the safe, efficient, and effective conversion to a remote work force without compromising the research process.


Asunto(s)
COVID-19/terapia , Ensayos Clínicos como Asunto/organización & administración , Pandemias/prevención & control , Distanciamiento Físico , Servicio de Cirugía en Hospital/organización & administración , COVID-19/epidemiología , California , Ensayos Clínicos como Asunto/estadística & datos numéricos , Hospitales Universitarios/organización & administración , Hospitales Universitarios/estadística & datos numéricos , Hospitales Universitarios/tendencias , Humanos , Seguridad del Paciente , Selección de Paciente , Servicio de Cirugía en Hospital/estadística & datos numéricos , Servicio de Cirugía en Hospital/tendencias
16.
Rev. argent. cir ; 112(1): 30-42, mar. 2020. graf, tab
Artículo en Inglés, Español | LILACS | ID: biblio-1125779

RESUMEN

Antecedentes: las cirujanas en la Argentina experimentan barreras en el ámbito laboral y personal tratando de lograr sus objetivos profesionales. El objetivo de esta investigación fue explorar las barreras que enfrentan las cirujanas en su carrera laboral en las tres principales ciudades de la República Argentina. Material y métodos: estudio exploratorio transversal. Se utilizaron encuestas anónimas a cirujanas durante un período de 6 meses. Resultados: un 59% de las cirujanas son solteras y no viven en pareja. Aquellas con hijos son las principales encargadas de la crianza. Los esposos o convivientes aparecen en tercer lugar, con un muy bajo porcentaje de responsabilidad en la tarea. En la mayoría de los espacios laborales no existe un sistema que facilite el cuidado de hijos en su trabajo. El 65% afirma haber dejado de presentar trabajos científicos luego de la maternidad. Solo un 26% de los pacientes ha rechazado sus servicios en favor de ser intervenido por un cirujano hombre. Por el contrario, un 42% de los jefes ha rechazado ser acompañado en cirugías por cirujanas. Casi un 85% de las cirujanas ha recibido comentarios alusivos a su sexualidad durante su trabajo. Conclusión: las estructuras organizacionales quirúrgicas operan como un marco normativo estructurador de prácticas y discursos que han construido, en el nivel simbólico, subjetivo e institucional, las desigualdades entre mujeres y varones en el ámbito de la actuación médica. La feminización del sector en los últimos tiempos y la salida de la mujer al ámbito laboral no implican necesariamente la equidad de género.


Background: Women surgeons in Argentina face barriers in the workplace and in their personal life when trying to achieve their professional goals. The aim of this investigation was to explore the career barriers women surgeons face in the three main cities of Argentina. Material and methods: We conducted an exploratory cross-sectional study. Anonymous surveys were administrated to women surgeons during a six-month period. Results: Among survey respondents, 59% were single and did not live with a partner. Those with children are the primary carers. Spouses or partners appear in third place, with a very low percentage of responsibility as carers. Most workplaces where female surgeons work do not have childcare facilities. Sixty-five percent of the survey respondents had not presented scientific papers after having children. Only 26 percent of patients had rejected their services in favor of a male surgeon and 42% of head surgeons had refused to be assisted by female surgeons. Almost 85% of women surgeons have received comments about their sexuality during their work. Conclusions: The organizational structures of surgery departments work as a structured regulatory framework of practices and speeches that have constructed the inequalities between women and men in the field of medical action at the symbolic, subjective and institutional level. The recent feminization of the surgical field and the entrance of women in the workplace do not necessarily imply gender equality.


Asunto(s)
Humanos , Femenino , Adulto , Persona de Mediana Edad , Adulto Joven , Servicio de Cirugía en Hospital/estadística & datos numéricos , Mujeres Trabajadoras/psicología , Rol de Género , Servicio de Cirugía en Hospital/tendencias , Mujeres Trabajadoras/estadística & datos numéricos , Lactancia Materna , Embarazo , Estudios Transversales , Acoso Sexual/estadística & datos numéricos , Acoso no Sexual/estadística & datos numéricos , Internado y Residencia/estadística & datos numéricos
17.
Ann R Coll Surg Engl ; 102(4): 271-276, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31918560

RESUMEN

INTRODUCTION: There has been regular dialogue regarding the importance of developing clinical networks to compensate for the steady decline in general paediatric surgery performed by adult surgeons. Despite this dialogue, there are no contemporary published data to quantify the issue. This report documents patterns in delivery of general paediatric surgery in England and shows what is being performed where and by whom. MATERIALS AND METHODS: Using the Surgical Workload Outcome Database, we compared hospital-level data between 2009 and 2017. Inclusion criteria were children under 18 years admitted to NHS hospitals in England for elective general paediatric surgery. Data were analysed with an online statistical package performing paired t-tests. RESULTS: There was no real change in the overall number of elective general paediatric surgical marker cases, but the type mix has changed. The number of marker cases performed by adult surgeons fell by 34% (4699 vs 3090 p < 0.05). The number of marker cases performed by specialist paediatric surgeons increased by 21% (8184 vs 9862 p < 0.05). This increase in workload occurred in both tertiary (21% increase) and peripheral (18% increase) centres. When analysing data by operation type it was apparent that 78% of the increased workload was attributable to an increase in orchidopexy rate. CONCLUSION: Best practice is to treat children close to home by staff with the right skills. This study shows significant shifts in the general paediatric surgical workload. It is important to monitor these trends for successful succession planning as well as configuration of services.


Asunto(s)
Procedimientos Quirúrgicos Electivos/tendencias , Hospitales Generales/tendencias , Hospitales Pediátricos/tendencias , Servicio de Cirugía en Hospital/tendencias , Carga de Trabajo/estadística & datos numéricos , Adolescente , Niño , Preescolar , Bases de Datos Factuales/estadística & datos numéricos , Procedimientos Quirúrgicos Electivos/estadística & datos numéricos , Inglaterra , Femenino , Planificación Hospitalaria/organización & administración , Hospitales Generales/estadística & datos numéricos , Hospitales Pediátricos/organización & administración , Hospitales Pediátricos/estadística & datos numéricos , Humanos , Lactante , Recién Nacido , Masculino , Especialización/estadística & datos numéricos , Especialización/tendencias , Medicina Estatal/organización & administración , Medicina Estatal/estadística & datos numéricos , Medicina Estatal/tendencias , Cirujanos/estadística & datos numéricos , Cirujanos/tendencias , Servicio de Cirugía en Hospital/estadística & datos numéricos
19.
Int J Clin Pharm ; 41(1): 13-17, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30610549

RESUMEN

Background Data is lacking on types and severities of drug-related problems (DRPs) in hospitalized surgical patients in China. Objective To identify and categorize types and causes of DRPs, and to assess severities of these DRPs. Setting An academic teaching hospital in Chongqing, China. Method We retrospectively reviewed all medication orders for patients in six surgical departments during a six-month period. DRPs were classified using the Pharmaceutical Care Network Europe (PCNE) classification, and the severity ratings of these DRPs were based on the National Coordinating Council for Medication Error Reporting and Prevention (NCCMERP) classification. Main outcome measure The number, types, causes and severities of the DRPs. Results A total of 291,944 medication orders in 10,643 patients were reviewed, and 3548 DRPs were identified. The average DRP number per patient was 0.3. The most common problem was treatment effectiveness (39.9%) and the major cause of the problems was dose selection (47.0%). Total 80.1% of the DRPs were rated at severity categories B to D (causing no or potential harm), whereas 19.9% were rated as categories E to H (causing actual harm). Conclusion DRPs are common in surgical patients, and prospective pharmacist medication order review services are needed to improve patients' pharmaceutical care.


Asunto(s)
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/clasificación , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/diagnóstico , Hospitalización/tendencias , Servicio de Cirugía en Hospital/clasificación , Servicio de Cirugía en Hospital/tendencias , Adulto , Anciano , China/epidemiología , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos
20.
Medicina (Kaunas) ; 54(6)2018 Nov 26.
Artículo en Inglés | MEDLINE | ID: mdl-30486311

RESUMEN

Background and objective: Bacterial multidrug resistance is particularly common in Gram-negative bacilli (GNB), with important clinical consequences regarding their spread and treatment options. The aim of this study was to investigate the trend of multidrug-resistant GNB (MDR-GNB) in high-risk hospital departments, between 2000⁻2015, in intervals of five years, with the intention of improving antibiotic therapy policies and optimising preventive and control practices. Materials and methods: This is an observational, retrospective study performed in three departments of the most important tertiary healthcare unit in the southwestern part of Romania: the Intensive Care Unit (ICU), the General Surgery Department (GSD), and the Nutrition and Metabolic Diseases Department (NMDD). MDR was defined as acquired resistance to at least one agent in three or more antimicrobial categories. Trends over time were determined by the Cochran⁻Armitage trend test and linear regression. Results: During the study period, a total of 2531 strains of MDR-GNB were isolated in 1999 patients: 9.20% in 2000, 18.61% in 2005, 37.02% in 2010, and 35.17% in 2015. The most significant increasing trend was recorded in the ICU (gradient = 7.63, R² = 0.842, p < 0.001). The most common MDR-GNB in the ICU was isolated from bronchoalveolar aspiration samples. Concerning the proportion of different species, most of the changes were recorded in the ICU, where a statistically significant increasing trend was observed for Proteus mirabilis (gradient = 2.62, R² = 0.558, p < 0.001) and Acinetobacter baumannii (gradient = 2.25, R² = 0.491, p < 0.001). Analysis of the incidence of the main resistance phenotypes proportion identified a statistically significant increase in carbapenem resistance in the ICU (Gradient = 8.27, R² = 0.866, p < 0.001), and an increased proportion of aminoglycoside-resistant strains in all three departments, but more importantly in the ICU and GSD. Conclusion: A statistically significant increasing trend was observed in all three departments; the most significant one was recorded in the ICU, where after 2010, carbapenem-resistant strains were isolated.


Asunto(s)
Farmacorresistencia Bacteriana Múltiple , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Gramnegativas/aislamiento & purificación , Infecciones por Bacterias Gramnegativas/epidemiología , Atención Terciaria de Salud , Antibacterianos/farmacología , Antibacterianos/uso terapéutico , Lavado Broncoalveolar , Carbapenémicos/uso terapéutico , Bacterias Gramnegativas/clasificación , Infecciones por Bacterias Gramnegativas/mortalidad , Humanos , Incidencia , Unidades de Cuidados Intensivos , Estudios Retrospectivos , Factores de Riesgo , Rumanía/epidemiología , Servicio de Cirugía en Hospital/tendencias , Resistencia betalactámica
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